Madonna is to direct the MGM drama Taking Flight, based on the life of ballerina Michaela De Prince.
The studio has been developing Taking Flight since 2015, when it first bought rights to Michaela and Elaine DePrince's memoir, Taking Flight: From War Orphan to Star Ballerina.
The book follows Michaela DePrince's life from an orphan in war-torn Sierra Leone to a world-renowned ballerina.
"Michaela's journey resonated with me deeply as both an artist and an activist who understands adversity," Madonna said.
"We have a unique opportunity to shed light on Sierra Leone and let Michaela be the voice for all the orphaned children she grew up beside. I am honoured to bring her story to life."
Madonna will direct from a screenplay by Camilla Blackett.
Madonna made her feature directing debut on the 2008 British comedy Filth and Wisdom. She also helmed and co-wrote 2011's W.E., which chronicled the relationship between King Edward VIII and American divorcee Wallis Simpson.
Her upcoming projects include co-writing and directing a film adaptation of Andrew Sean Greer's novel The Impossible Lives of Greta Wells.
Madonna also produced and wrote I Am Because We Are, a documentary about Malawi's million orphans in the wake of the AIDS pandemic.